Tuesday, January 24, 2006

Sirna Granted Patent for RNAi Production

Sirna Therapeutics, Inc. (Nasdaq: RNAI), announced today that the U.S. Patent and Trademark Office has granted Patent No. 6,989,442 for the chemical synthesis and manufacturing of ribonucleic acids. The patent broadly covers a process for the synthesis, deprotection and purification of nucleic acids with one or more ribonucleotides.

This process is critical for the efficient synthesis of RNA at high yields and high purity and is applicable to both small- and large-scale production of oligonucleotides such as siRNAs and aptamers. The patent further expands Sirna's leadership position in the area of synthesis and manufacturing of GMP quality RNA which is required for both chemically modified and unmodified siRNA-based therapeutics.

Sirna now holds 48 issued patents with an additional 240 plus patent applications still pending.

In order to manufacture siRNA it takes a synthesis protocol encompassing some 150 steps. This newly issued patent covers the required steps to manufacture siRNA material that achieves not only yields in excess of 60% but of unparalleled quality too.

2 comments:

Anonymous said...

Neurolinguistic Programming

In the early 1970s in America Richard Bandler, then a young college student studied the work of Fritz Perls and later Virginia Satir and found that he could reproduce their high-level therapy skills to a degree that even surprised him. Bandler seemed to have a natural ability to mimic (model) the language patterns by Virginia and Fritz.

At the University of California at Santa Cruz, Bandler who was well versed in the teachings of patterns in mathematics and computers teamed up with a college professor, John Grinder to help him understand the processes that were at work. Soon Bandler and Grinder, who used what he knew about patterns in linguistics, created a new model for personal growth called NeuroLinguistic Programming.

Bandler and Grinder had set out to model the hypnotic skills of Milton Erickson. They had astounding results. They built a communication model about human "thinking" and "processing" and used that model of how we see images, hear sounds, reproduces smells and tactile experiences in our mind to track and model the structure of subjective experiences.

Sounds very complicated but really it works very simply. Here is an example as used by Paul McKenna - probably the best & most successful hypnotist in the world.

Close your eyes and think of a negative memory. Become involved in the situation as best as you can. Feel the emotions that you felt, see the things you saw and hear the things you heard.

Now take that memory and project it onto a mental screen seeing yourself in the picture. Put a frame around the picture and view it as if it is an old photograph. Next drain all the colour from the picture and shrink the screen to the size of a matchbox.

Have the feelings associated with the picture decreased in any way?

Another good example of NLP involves Anchors. Have you ever smelt a certain perfume or aftershave and had it remind you of a certain person or situation? Gone to a certain place that brings feelings long forgotten flooding back? Or been in any situation that creates emotional responses that would not normally be associated with it? Well if you can answer yes to any of these then you have experienced anchors. Some anchors are associated with positive feelings and some with negative emotions. However, you should be aware that anchors can be consciously installed or already existing ones altered. Here is an example:

Think of a time when you were really happy. If you can't think of one then imagine something that would make you feel really happy. See what you would see, hear what you would hear and feel what you would feel. Really get into the picture and try to experience it as though it were happening now.

Now brighten the colours and make them richer. Increase the volume. Make the picture bigger, brighter, louder. That's it and more and more....

Now press your first finger against your thumb and fully experience your happy feelings. Do this everyday for 2 weeks and you will create an anchor that will instantly recreate these feelings. Whenever you want to feel like that again just press your thumb and first finger together and wham the feelings will come flooding back! Don't believe me? Just try it and see!!! personal development

Anonymous said...

What are your 50,000 thoughts a day creating?
Our thoughts create our reality. This is a simple truth known by all people involved on the spiritual path. It is one of the most taught universal principles in the personal development field. Yet it is one of the most misunderstood!
People practice visualisation, affirmations, they use hypnosis, subliminal programming or countless other tools to transform their lives. However they fail to recognise one key area in their lives that hinder these wonderful techniques from being effective.
They sit day after day visualising their perfect scene and yet nothing happens. Why? They have followed all the instructions to the letter! They have chanted and imagined! They have formed a colourful, vibrant scene in their minds and affirmed that this is their reality. Then all of a sudden things get worse! What is going on?
Would you like to know the secret? Would you like to know why these people get no results? Would you like to hear one powerful statement that explains everything?
Yes?
Good. I will tell you why these people get no results or even opposite results to those they are aiming for -simply because of the following truth. Consciously controlled thoughts such as visualisations do not materialise - ALL thoughts materialise!!!
Most people believe that if they visualise for 10 minutes a day their lives will magically transform. This is not the case. You must change your core thinking. You think approx. 50,000 thoughts a day. How many of those thoughts are working against your ten minute visualisation?
You can control the thoughts that enter your mind by changing the way you view the world. You can decide which thoughts you give energy to and which thoughts you discard.
The thoughts that you follow and give energy to become more dominant than the thoughts you discard. Your subconscious mind records these as your dominant picture on the issue at hand. You then move towards this picture because your subconscious mind starts making your outside world reflect the picture that you have stored internally.
Your mind should be on whatever you want. The picture you need to have is a positive vision of you already having achieved your goal. To realise this vision you need to focus and concentrate. Remember thoughts are real, they create your reality.
Let's say you have been visualising a new house. You spend your ten minutes in meditation picturing yourself living in your dream home. You finish your session and get up feeling positive that you will achieve your goal. Then during the day you get a heating bill through the post and exclaim "Oh no look how expensive this is I cannot afford to heat this house". Where is your focus in the present moment? What are you affirming? You are telling your subconscious mind that you cannot deal with what you have. You are affirming that your life is not how you want it to be. If you knew without doubt that within a week you would be moving to your new home would you honestly be worried about a heating bill? Perhaps other doubts creep in like "I should be happy with what I have", or "I will never get this house looking the way I want it" and so on and so on.
These thoughts that are not aligned with your goal. You are not giving complete attention to what you want. Whilst you are dealing with these other lines of thought your attention is not on your goal.
If you are aware of your thoughts you will suddenly realise that you have spent much more energy on counter productive thoughts than on creating a dominant picture of the goal you want.
Point your focus in the direction of you're the life you want. Think about what you want NOT what you don't want. It's that simple.
Your focus determines your reality. Change your focus and you change your life. lucid dream