Tuesday, June 28, 2005

Myogen is Hunkering Down

Three cheers for Myogen (MYOG).

The company reported yesterday that the enoximone program, for the treatment of advanced stage chronic heart failure, has been terminated as a result of their two phase III trials failing to demonstrate a statistically significant benefit for any of the three co-primary endpoints.

Despite the news something needs to be said for the talented management team, led by J. William Freytag, Mike Bristow and Joe Turner, for creating a richly diverse portfolio that though disappointed by the enoximone results Myogen will now hunker down and focus its attention on not one but two other late-stage clinical programs.

Two phase III trials were initiated in early ’04 with ambrisentan, for the treatment of patients with pulmonary arterial hypertension, and in July ’04 a phase IIb trial commenced for darusentan, an oral therapy for patients with uncontrolled hypertension. In addition, the company currently markets Perfan® in eight European countries to treat patients with acute decompensated heart failure and, also boasts a robust research and discovery program in cardiac signaling, fetal genes, cardiogenomics & cardioproteomics and, Myogen can also lay claim to perhaps the world’s largest heart tissue bank.

A true test of a champion is when knocked down to get right back up and keep fighting. Myogen not only has plenty of fight left in her but also plenty of cash to fund working capital requirements and capital expenditures through deep into 2006. But don’t just take my word for it – Wachovia Bank also released yesterday their upgrade of Myogen from market perform to outperform.

9 comments:

Anonymous said...

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Rhodiola Rosea, also known as Golden Root, is a native plant of arctic Siberia. For centuries it has been used by eastern European and Asian cultures for physical endurance, work productivity, longevity, resistance to high altitude sickness, and to treat fatigue, depression, anemia, impotence, gastrointestinal ailments, infections, and nervous system disorders.

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The effects of Rhodiola Rosea have also been tested on stress and anxiety from both physical and emotional sources. A report by the American Botanical Council states that "Most users find that it improves their mood, energy level, and mental clarity." They also report on a study that indicated Rhodiola Rosea could increase stress tolerance while at the same time protecting the brain and heart from the physical affects of stress.

This report included details of studies which highlight the overall health benefits of Rhodiola Rosea.

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Essential oils, roots and herbs can be used in a variety of ways to promote healthy living and stress testing. They are used to create natural remedies for treating ailments common to both people and animals, to add flavor to food, to make perfumes and to create environmentally friendly cleaning products.

You do not have to own a garden to tap into the benefits of plants, roots and herbs. A few herb pots located by a sunny window are enough to get you started. Then, all you need are some essential oils and you are ready to go.

For therapeutic purposes, only the purest oils will do. It is possible to be fooled into thinking that you are purchasing a pure oil. Often, a lesser quality blend of several oils is used to mimic the properties of the pure oil. Blended oils are acceptable for fragrance purposes such as for perfuming a room, but pure oils are a "must" for medicinal purposes.

A reasonable guide to the purity of an essential oil is its price. Pure essential oils are generally more expensive. Common oils such as lavender and geranium are much cheaper than frankincense and carnation oil. It is advisable to become familiar with essential oil prices and then rely on this knowledge when purchasing oils from unfamiliar sources. Keep in-mind that you will generally get what you pay for. A price list from a reputable dealer is a valuable resource when purchasing essentials oils.

Usually, pure essential oils cannot be applied directly to the skin and must be mixed in a base oil to reduce their strength. Base oils such as almond oil or wheatgerm oil are commonly used for this purpose. Base oils are generally derived from seeds, nuts or vegetables and allow you to create essential oil remedies that can be massaged into the skin.

So, what do you need to get started with essential oils and natural remedies?

Without a doubt, Lavender is one of the most useful and desirable oils. Not only does it work wonders on cuts, bruises and burns, it also aids sleep and helps with relaxation.

The Tea Tree and Eucalyptus oils are useful for treating a variety of respiratory ailments. These are excellent for the treatment of colds and coughs. They can be massaged into the chest or burned in an oil burner to help clear the airways and prevent congestion. Tea Tree oil is a natural antiseptic and can be dabbed on cuts, bites and stings. It is often used to treat spots and pimples and when diluted with water, acts as a mouth gargle (keep in-mind it should never be swallowed).

Another basic antiseptic is Geranium oil. With its distinctive perfume and pain relieving properties, it is a necessary inclusion when starting out.

Peppermint oil should also be purchased as it treats digestive complaints and may be used in preparations for freshening breath.

For fragrant perfumes and establishing ambience in a room, buy some Patchouli and Ylang-ylang oils. Often combined in scented candles and air fresheners, a few drops of each in an oil burner creates a wonderfully perfumed home. Orange oil mixed with Cinnamon oil is a lovely winter alternative that evokes seasonal, holiday smells. Besides their perfume qualities, all four of these oils have other properties. Patchouli treats eczema and dandruff. Ylang-ylang is reputed to relieve stress, palpitations and high blood pressure. Orange is used in natural remedies for depression and nervous tension and Cinnamon is excellent for warts and viral infections.

The herbs, Thyme and Rosemary can be grown in pots and used when needed. To create essential oils from herbs, stew some large amounts in pure water, collect the steam and cool it. The oil will rise to the top of the drained water and can be collected with an eyedropper. Alternatively, a "flower still" can be purchased to make the job easier. Thyme and Rosemary are both antiseptics and can be used in skin care preparations. They are also delicious when used in cooking.

Lemon oil and fresh lemons will purify water and, when mixed with honey, are effective remedies for colds and flu. Lemon and white vinegar are highly efficient cleaning agents that can be used for domestic cleaning tasks without damaging the environment. Use white vinegar as a natural disinfectant or mix it with water to clean windows and wooden floors. It is also handy to keep a bottle of white vinegar in your car if you swim in the ocean. It will bring instant relief from jellyfish stings.

Citronella oil is perfect in summer to keep the insects at bay. Another natural repellent is Garlic. Fleas will not bite a dog that has been eating garlic, so a few garlic capsules in the dog food are a cheap solution to your pet's flea problem. A soft collar soaked in Citronella will also do the job.

Garlic also helps to promote a healthy immune system when the weather turns cold and viruses begin to circulate. In fact, most of the oils and herbs listed above are effective in helping to prevent many common winter illnesses.

Whether you are looking for remedies or nature friendly products to use around the house, the oils and herbs suggested above should help get you started. You will be ready to make some healthy changes in your way of life!

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