Isogenis is focused upon novel immune modulating therapeutics for the treatment of immune disorders, genetic diseases, and transplant tolerance. A number of animal veto effect exploitation model transplantation systems have been developed for: pancreatic islet, liver, and heart transplantations, and have subsequently validated that their approaches have permanently protected tissues from rejection.
Current foci of product development include:
- Supressing Hybrid Antibodies - Engineered human antibody fragments coupled with human CD8 proteins to induce the veto effect and prevent transplant rejection.
- Viral Vectors - Engineered viruses that deliver the CD8 gene to induce transplant tolerance.
- Genetic Disease Therapeutics - Vectors developed to deliver genes repairing a genetic defect while simultaneously using veto technology to protect the gene product from rejection.
So what exactly is the veto effect? It is a phenomenon that happens when CD8 protein expressed on the surface of a T cell recognizes another CD8 protein on the target cell. When this CD8 is recognized, the cytotoxic T Lymphocyte begins apoptosis. The immunological response is “vetoed” for this particular cell, but the immune system still functions normally.
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